Microbial flora, probiotics, Bacillus subtilis and the search for a long and healthy human longevity

نویسندگان

  • Facundo Rodriguez Ayala
  • Carlos Bauman
  • Sebastián Cogliati
  • Cecilia Leñini
  • Marco Bartolini
  • Roberto Grau
چکیده

Probiotics are live microorganisms that have beneficial effects on host health, including extended lifespan, when they are administered or present in adequate quantities. However, the mechanisms by which probiotics stimulate host longevity remain unclear and very poorly understood. In a recent study (Nat. Commun. 8, 14332 (2017) doi: 10.1038/ncomms14332), we used the spore-forming probiotic bacterium Bacillus subtilis and the model organism Caenorhabditis elegans to study the mechanism by which a probiotic bacterium affects host longevity. We found that biofilm-proficient B. subtilis colonized the C. elegans gut and extended the worm lifespan significantly longer than did biofilm-deficient isogenic strains. In addition to biofilm proficiency, the quorum-sensing pentapeptide CSF and nitric oxide (NO) represent the entire B. subtilis repertoire responsible for the extended longevity of C. elegans. B. subtilis grown under biofilm-supporting conditions synthesized higher levels of NO and CSF than under planktonic growth conditions, emphasizing the key role of the biofilm in slowing host aging. Significantly, the prolongevity effect of B. subtilis was primarily due to a downregulation of the insulin-like signaling system that precisely is a key partaker in the healthy longevity of human centenarians. These findings open the possibility to test if the regular consumption of B. subtilis incorporated in foods and beverages could significantly extend human life expectancy and contribute to stop the development of age-related diseases.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Estimation of metabolizable energy equivalency of Bacillus Subtilis spore for male broiler chickens

There are many studies on the effects of probiotics on performance of broiler chickens, but none of them has evaluated the metabolizable energy (ME) equivalency values of probiotics. The aim of this study was to determine the metabolizable energy equivalency value of Bacillus subtilis spore and its potential for decreasing feed ME content and cost. One hundred seventy-six day-old male broilers ...

متن کامل

Effects of Bacillus subtilis KD1 on broiler intestinal flora.

A novel Bacillus subtilis KD1 strain was isolated and identified from healthy broilers, and its phylogenetic classification was subsequently analyzed. To evaluate its probiotic availability, its growth characteristics and tolerance for the gut environment were evaluated in vitro. The results suggest that B. subtilis KD1 is superior in secreting neutral protease and is highly tolerant of gastric...

متن کامل

Effects of Lactobacillus casei probiotics on growth performance, blood parameters and intestinal microbial flora in juvenile goldfish (Carassius auratus)

Lactobacillus casei probiotic is one of the probiotics used in aquaculture industry. The aim of this study was to evaluate the effect of Lactobacillus casei probiotic on the growth performance, blood parameters, and intestinal microbial flora in goldfish (Carassius auratus) for 60 days. In this study, 180 fish with an average weight of 10.11± 0.16 g were randomly distributed into two treatments...

متن کامل

The Influence of Some Probiotics on the Growth Performance and Intestinal Microbial Flora of O

The objective of the present study was to understand the influence of some types of probiotics on the growth parameters and the intestinal microbial flora of O. niloticus. The fish were divided into three groups, the first one fed on diet supplemented with dead Saccharomyces cerevisae yeast, the second group fed on diet supplemented with live Bacillus subtilis and Saccharomyces cerevisae while ...

متن کامل

Effect of Household Cooking Methods on the Viability of Bacillus Probiotics Supplemented in Cooked Sausage

Background and Objectives: The use of Bacillus probiotics is an interesting way for manufacturing healthier meat and meat products as functional foods and also a valuable solution for overcoming the constraints related to the stability of probiotic strains of Lactobacillus and Bifidobacterium during processing and storage of foods. This work is an attempt to investigate the influence of common ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره 4  شماره 

صفحات  -

تاریخ انتشار 2017